Foster children Andi and Bruce have been placed with a flaky couple who care more for their aspiring rock careers than their charges. Their mischievous tendencies repeatedly get them into trouble. After a close call with the local pound, the kids end up searching for Friday, their secretly adopted dog, in an abandoned old hotel where they find several other stray dogs seeking shelter. They, along with three other local kids, begin caring for the strays....

Maya Dolittle takes on a job in Hollywood helping a chihuahua belonging to a famous actress, and the actress and her agent convince Maya to star in her own reality show.

Maya's dream of going to vet school is put on hold when she gets a call from the President of the United States. It seems the First Dog is out of control and the President needs her help. It's up to Maya and her own dog, Lucky, to stop a canine catastrophe from becoming a national crisis.

Maya Dolittle visits Washington, D.C., where she meets the president and finds herself talking to a variety of animals, including a wallaby named Bruce.